Automated parallel peptide synthesis instruments

The Swedish Biotage provides options from manual instruments, through semi-automated ones, to fully automated systems for laboratories which synthesize peptides. In addition to the systems that carry out conventional reactions at room temperature, also systems that synthesize peptides with microwaves are available.

Syro I and Syro II

With the Syro I and Syro II parallel peptide synthesizer instruments the multi-step time-consuming peptide syntheses can be performed at room temperature, in an automatic, pre-programmed way. The Syro I has a reactor block for 24 reaction vessels of 5 ml or 48 vessels of 2 ml. The reagents are injected into the instrument with a liquid-handling robot arm helped by 2 digital syringe pumps. The Syro II has 2 robot arms and there is space for 2 optional reactor blocks, while the liquid dosing of the reagents and other liquids is provided by 4 syringe pumps. The mixing of the substances participating in the reactions is carried out by the built-in Vortex mixer in the case of both instruments. The control of Syro I and Syro II peptide synthesizers is performed by the Syro XP control software installed on a separate computer.

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The Syro I, Syro II and Syro Wave instruments can be supplemented with the inert gas rinsable reactor blocks and with the accessory that facilitates ”tip” synthesis. To perform cleavage reactions, the transfer module, containing the separate 24-position Vortex mixer, can be used. In this way, the access of the aggressive solvents into the peptide synthesizer can be avoided.